Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse Events

This is a registry record, not a result. A trial being listed, recruiting or completed says nothing by itself about whether the compound works or is safe.

Registry numberNCT07607587
StatusRecruiting
PhasePhase 1
SponsorNovo Nordisk A/S
Enrollment114 participants
DesignInterventional, Randomized, Parallel, Masking: Quadruple
ConditionsObesity; Overweight
InterventionsCagrilintide; Placebo (matched to Cagrilintide)
StartMay 29, 2026
Primary completionNov 19, 2027
Study completionNov 19, 2027
Results postedNot yet
Registry last updatedJun 25, 2026

Compounds on this site that cite this trial

What the registry says the trial is about

The purpose of this clinical study is to look at the safety of the medicine Cagrilintide when compared to placebo in people who do not tolerate marketed glucagon-like peptide-1 (GLP-1) therapies and who live with overweight or obesity. Participants will get either Cagrilintide (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participant will get is decided by chance. The study will last for about 8 months.

Primary outcomes

These are what the trial was designed to measure first. They are registered in advance, which is what makes a later result checkable.

Outcome measureTime frame
Percentage of participants on standard dose or higher dose (yes/no) of cagrilintide and placeboAt week 26

Source: ClinicalTrials.gov (U.S. National Library of Medicine). Last checked against the registry on Oct 3, 2026. See the trial changes feed for what has changed recently.