A Study to Investigate Weight Management With LY3841136 and Tirzepatide (LY3298176), Alone or in Combination, in Adult Participants With Obesity or Overweight With Type 2 Diabetes

This is a registry record, not a result. A trial being listed, recruiting or completed says nothing by itself about whether the compound works or is safe.

Registry numberNCT06603571
StatusCompleted
PhasePhase 2
SponsorEli Lilly and Company
Enrollment367 participants
DesignInterventional, Randomized, Parallel, Masking: Double
ConditionsObesity; Overweight
InterventionsLY3841136; Tirzepatide; Placebo
StartSep 20, 2024
Primary completionJul 1, 2026
Study completionSep 14, 2026
Results postedNot yet
Registry last updatedSep 29, 2026

Compounds on this site that cite this trial

What the registry says the trial is about

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to investigate the safety and efficacy of LY3841136 for chronic weight management alone or in combination with Tirzepatide across a wide dose range in participants with Type 2 Diabetes. Participation in the study will last about 64 weeks.

Primary outcomes

These are what the trial was designed to measure first. They are registered in advance, which is what makes a later result checkable.

Outcome measureTime frame
Percent Change from Baseline in Body WeightBaseline, Week 48

6 secondary outcomes also registered. See the registry record for the full list.

Source: ClinicalTrials.gov (U.S. National Library of Medicine). Last checked against the registry on Oct 3, 2026. See the trial changes feed for what has changed recently.