A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide

This is a registry record, not a result. A trial being listed, recruiting or completed says nothing by itself about whether the compound works or is safe.

Registry numberNCT06897475
StatusRecruiting
PhasePhase 2
SponsorEli Lilly and Company
Enrollment200 participants
DesignInterventional, Randomized, Parallel, Masking: Double
ConditionsType 2 Diabetes
InterventionsLY3457263; Placebo
StartMar 28, 2025
Primary completionMay 2027
Study completionJun 2027
Results postedNot yet
Registry last updatedSep 14, 2026

Compounds on this site that cite this trial

What the registry says the trial is about

The purpose of this study is to measure the change in hemoglobin A1c (HbA1c) with LY3457263 compared with placebo in participants with type 2 diabetes who are not at HbA1c goal when treated with a stable dose of semaglutide or tirzepatide. Participation in the study will last about 9 months.

Primary outcomes

These are what the trial was designed to measure first. They are registered in advance, which is what makes a later result checkable.

Outcome measureTime frame
Change from Baseline in Hemoglobin A1c (HbA1c)Baseline, Week 24

2 secondary outcomes also registered. See the registry record for the full list.

Source: ClinicalTrials.gov (U.S. National Library of Medicine). Last checked against the registry on Oct 3, 2026. See the trial changes feed for what has changed recently.