Kisspeptin Administration Subcutaneously to Patients With Reproductive Disorders

This is a registry record, not a result. A trial being listed, recruiting or completed says nothing by itself about whether the compound works or is safe.

Registry numberNCT05633966
StatusCompleted
PhasePhase 1
SponsorStephanie B. Seminara, MD
Enrollment13 participants
DesignInterventional, Na, Single Group, Masking: None
ConditionsHypothalamic Amenorrhea; Hypogonadotropic Hypogonadism
InterventionsKisspeptin 112-121
StartDec 16, 2022
Primary completionAug 31, 2025
Study completionAug 31, 2025
Results postedNot yet
Registry last updatedOct 3, 2025

Compounds on this site that cite this trial

What the registry says the trial is about

The goal of this study is to see whether kisspeptin, a naturally occurring hormone, can stimulate the release of other reproductive hormones in women with hypothalamic amenorrhea (HA). The investigators are also examining whether kisspeptin can help women release eggs from their ovaries. Kisspeptin will be administered subcutaneously (SC) for two weeks in a pulsatile fashion. Ultrasound monitoring of ovarian follicular growth and frequent blood sampling (every 10 minutes for up to two hours) will be performed to assess the physiologic response to kisspeptin over time.

Primary outcomes

These are what the trial was designed to measure first. They are registered in advance, which is what makes a later result checkable.

Outcome measureTime frame
The proportion of participants that achieve development of a mature follicle or show evidence of ovulation2 weeks

1 secondary outcome also registered. See the registry record for the full list.

Source: ClinicalTrials.gov (U.S. National Library of Medicine). Last checked against the registry on Oct 30, 2026. See the trial changes feed for what has changed recently.