Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Type 2 Diabetes (ZUPREME 2)

This is a registry record, not a result. A trial being listed, recruiting or completed says nothing by itself about whether the compound works or is safe.

Registry numberNCT06926842
StatusCompleted
PhasePhase 2
SponsorZealand Pharma
Enrollment221 participants
DesignInterventional, Randomized, Parallel, Masking: Double
ConditionsOverweight; Type 2 Diabetes; Obesity
InterventionsPetrelintide; Placebo
StartApr 22, 2025
Primary completionAug 13, 2026
Study completionAug 13, 2026
Results postedNot yet
Registry last updatedSep 9, 2026
CollaboratorsParexel

Compounds on this site that cite this trial

What the registry says the trial is about

The main purpose of this study is to investigate efficacy and safety of three doses of petrelintide versus placebo in participants with overweight or obesity and type 2 diabetes.

Primary outcomes

These are what the trial was designed to measure first. They are registered in advance, which is what makes a later result checkable.

Outcome measureTime frame
Percentage Change in Body WeightFrom Baseline (Day 1) to Weeks 28

15 secondary outcomes also registered. See the registry record for the full list.

Source: ClinicalTrials.gov (U.S. National Library of Medicine). Last checked against the registry on Oct 30, 2026. See the trial changes feed for what has changed recently.

More trials of Petrelintide

Research area: Metabolic and incretin. Every registered trial we follow is in the clinical trial tracker, and the labels used on this page are explained in our evidence standards.