Effect of Retatrutide Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone (TRANSCEND-T2D-1)

This is a registry record, not a result. A trial being listed, recruiting or completed says nothing by itself about whether the compound works or is safe.

Registry numberNCT06354660
StatusCompleted
PhasePhase 3
SponsorEli Lilly and Company
Enrollment537 participants
DesignInterventional, Randomized, Parallel, Masking: Double
ConditionsDiabetes Type 2
InterventionsRetatrutide; Placebo
StartApr 10, 2024
Primary completionJan 22, 2026
Study completionFeb 20, 2026
Results postedNot yet
Registry last updatedMar 5, 2026

Compounds on this site that cite this trial

What the registry says the trial is about

The purpose of this study is to investigate the efficacy and safety of retatrutide compared with placebo in participants with Type 2 Diabetes and inadequate glycemic control. The study will last about 11 months and may include up to 11 visits.

Primary outcomes

These are what the trial was designed to measure first. They are registered in advance, which is what makes a later result checkable.

Outcome measureTime frame
Change from Baseline in Hemoglobin A1c (HbA1c) (%)Baseline, Week 40

13 secondary outcomes also registered. See the registry record for the full list.

Source: ClinicalTrials.gov (U.S. National Library of Medicine). Last checked against the registry on Oct 3, 2026. See the trial changes feed for what has changed recently.