A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight

This is a registry record, not a result. A trial being listed, recruiting or completed says nothing by itself about whether the compound works or is safe.

Registry numberNCT07357415
StatusActive not recruiting
PhasePhase 3
SponsorEli Lilly and Company
Enrollment600 participants
DesignInterventional, Randomized, Parallel, Masking: Double
ConditionsObesity; Overweight
InterventionsRetatrutide
StartJan 24, 2026
Primary completionOct 2028
Study completionNov 2028
Results postedNot yet
Registry last updatedJun 9, 2026

Compounds on this site that cite this trial

What the registry says the trial is about

The purpose of this study is to investigate the efficacy and safety of different retatrutide dose escalation schemes in participants without type 2 diabetes who have obesity or overweight. Participation in the study will last about 113 weeks.

Primary outcomes

These are what the trial was designed to measure first. They are registered in advance, which is what makes a later result checkable.

Outcome measureTime frame
Percent Change from Baseline in Body WeightBaseline, Week 104

7 secondary outcomes also registered. See the registry record for the full list.

Source: ClinicalTrials.gov (U.S. National Library of Medicine). Last checked against the registry on Oct 3, 2026. See the trial changes feed for what has changed recently.