This is a side-by-side of what is documented, not a ranking. Different compounds are studied for different things, in different people, at different amounts. A row that looks stronger for one compound does not make it the better choice for anyone.
| Adipotide | Retatrutide | |
|---|---|---|
| Highest evidence tier on the page | E3 Early human evidence Small, open-label, uncontrolled, case series, or a registered trial with no published results. | E2 Human clinical evidence Registered or peer-reviewed human trial with reported results. |
| Regulatory status | Not stated | In clinical development, not approved |
| Research area | Metabolic and incretin | Metabolic and incretin |
| Regulator-approved dose on file | No approved dose | No approved dose |
| Molecular formula | C111H206N36O28S2 (per PubChem) | Not reliably established |
| Molar mass | Not independently re-derived for this entry from an authoritative source; PubChem lists the compound under the formula above without an easily accessible listed molecular weight in the pages reviewed. Regard any specific mass figure seen elsewhere online as unverified until confirmed against PubChem directly. | Not reliably established |
| CAS number | 859216-15-2 | 2381089-83-2 |
| Registered trials on this site | 1 in the tracker | 7 in the tracker |
| Furthest registered phase | Phase 1 | Phase 3 |
| Trials currently active | 0 | 0 |
| Trial sponsors | M.D. Anderson Cancer Center | Eli Lilly and Company |
| What is not known | Whether Adipotide is safe or effective in a general, non-cancer, human obesity population; no such trial has ever been conducted. The specific human doses used in the one Phase I trial that was conducted (NCT01262664), and its results, since the trial was terminated with only... | Its molecular weight. Figures circulate in chemical catalogues, but no primary publication or regulatory document names one, so none is asserted here. Whether it prevents anything. No cardiovascular or kidney outcome data exist. TRIUMPH-Outcomes, 10,000 participants across 743 sites, has a primary completion date of... |
| Published trials covered on its page | Not stated | 7 |
| Amounts studied in those trials | Not stated | NCT04867785: Retatrutide 0.5, 4, 8 or 12 mg once weekly, dulaglutide 1.5 mg once weekly, or placebo; the 4 mg and 8 mg maintenance doses were each given twice, differing only in starting dose for 36 weeks NCT04881760: Retatrutide 1, 4, 8 or 12 mg once weekly, or placebo, across seven arms; the 4 mg and 8 mg arms each ran with a 2 mg or a 4 mg starting dose for 48 weeks TRIUMPH-1, NCT05929066: Retatrutide 4, 9 or 12 mg once weekly after a 16 week fixed escalation, or placebo, 1:1:1:1 for 80 weeks, with an optional 24 week extension for about 500 participants As reported on the compound page. Amounts are not comparable between compounds. |
Full pages: Adipotide and Retatrutide. See also the clinical trial tracker and how we grade evidence.
Educational reference, not medical advice. Trial data from ClinicalTrials.gov. Everything else is drawn from the compound pages on this site, each of which cites its sources.
