Choose any two compounds below to see them side by side. Each comparison page lines up the level of evidence behind each one, the registered clinical trials, and where each stands with regulators, so the differences are easy to see in one place.
This is a side-by-side of what is documented, not a ranking. Different compounds are studied for different things, in different people, at different amounts. A row that looks stronger for one compound does not make it the better choice for anyone.
| FOXO4-DRI | Klotho | |
|---|---|---|
| Highest evidence tier on the page | E3 Early human evidence Small, open-label, uncontrolled, case series, or a registered trial with no published results. | E3 Early human evidence Small, open-label, uncontrolled, case series, or a registered trial with no published results. |
| Regulatory status | Not approved for any medical use anywhere; no registered human clinical trial identified as of 2026, sold only as an unregulated research chemical. | Not stated |
| Research area | Longevity and mitochondrial | Longevity and mitochondrial |
| Regulator-approved dose on file | No approved dose | No approved dose |
| Molecular formula | C228H388N86O64 (as listed on PubChem and multiple peptide manufacturer specification sheets) | Not applicable at the protein level. |
| Molar mass | Approximately 5,358.15 g/mol (as reported by manufacturer specification sheets; note some vendor listings report slightly different values, likely reflecting salt form or rounding differences, which could not be independently reconciled against a certificate of analysis for this entry). | Full-length membrane protein approximately 130 kDa; the soluble form is a large glycoprotein fragment of comparable scale. |
| CAS number | 2460055-10-9 | Not reliably established. Klotho is a protein product, not a single registered small molecule/peptide, and vendor "Klotho peptide" products do not correspond to one verified CAS number. |
| Registered trials on this site | None linked yet | None linked yet |
| What is not known | FOXO4-DRI has not been tested in a registered human clinical trial, so there is no human pharmacokinetic data, no established human dose, and no formal human safety profile. Whether the selective senescent-cell-clearing effect seen in mice translates to any clinical benefit in humans, and whether... | There is no human dose because there has been no human trial of injectable Klotho protein or its fragments. Whether any effect seen in mice or the one primate study translates to humans, what a working human dose or route would look like, and whether... |
| Investigational pipeline | Not stated | Longevity |
Full pages: FOXO4-DRI and Klotho. See also the clinical trial tracker and how we grade evidence.
Educational reference, not medical advice. Trial data from ClinicalTrials.gov. Everything else is drawn from the compound pages on this site, each of which cites its sources.
Most requested comparisons
These are the pairings readers look for most often. Each opens a full side-by-side page.
Weight management compounds
- Retatrutide vs Tirzepatide
- Semaglutide vs Tirzepatide
- Retatrutide vs Semaglutide
- Retatrutide vs Survodutide
- Cagrilintide vs Semaglutide
- Orforglipron vs Semaglutide
- Mazdutide vs Tirzepatide
- Cagrilintide vs Eloralintide
- LY4086940 vs Retatrutide
- LY4086940 vs Orforglipron
Growth hormone related peptides
- Ipamorelin vs Sermorelin
- Sermorelin vs Tesamorelin
- CJC-1295 (no DAC) vs Ipamorelin
- CJC-1295 with DAC vs Ipamorelin
Repair and recovery
Longevity, mitochondria and brain
How to read a comparison
A side-by-side table can make two compounds look equally proven when they are not. Keep these points in mind as you read.
- Evidence level matters more than the headline. Every compound is placed on the same six-tier scale, from published human clinical trials down to community reports. A compound with large human trials and one with only animal studies are not comparable, even when both appear in the same table.
- Registered trials show what is being tested. A trial listed on ClinicalTrials.gov tells you a question is being studied, not that the answer is known. Check the status and phase. You can browse every tracked study on the clinical trial tracker and see recent registry updates in the trial changes feed.
- Regulatory status is specific to a formulation and a country. Approval of one product does not mean every version of that compound is approved.
- Different populations and doses limit direct comparison. Results from separate trials, run in different people over different periods, cannot be lined up as if they came from a head-to-head study unless a comparison page says a head-to-head study exists.
Frequently asked questions
Which compound is better?
These pages do not rank compounds or tell anyone what to use. They show what the published and registered evidence says about each one so you can see where the evidence is strong and where it is thin.
Why are some comparisons mostly empty on one side?
Many popular peptides have little or no human trial data. When that is the case, the comparison says so plainly rather than filling the gap with community claims.
Can I compare doses here?
Reported amounts are documented on each individual peptide page, with the source and evidence tier for every figure. If you need to work out concentrations, the reconstitution calculator is a math tool only and does not suggest an amount.
Where can I see every compound?
The full peptide library lists every entry,.
PeptideBlog is an educational reference compiled from public sources. It is not medical advice, and nothing here is a recommendation for or against any compound.
